Thursday, November 9, 2017

Hot and Cold Tumors



Hot and Cold Tumors

Each human malignancy is uniquely different from every other cancer, but from the point of view of immunotherapy, there are just two types of tumors: Hot and Cold. Likewise, there are two types of immunotherapy treatment: Immune response inducing and anti-immunosuppressive.

There are at least 100 different types of cancers if they are classified based on their tissue of origin. Looking more carefully at the cell type from which the malignant growth originates, there are at least 200 different types of cells in the human body, each of which can give rise to cancer. Even this is a superficial view since a cell type will behave differently when it is a different organ. Also, a tumor can be less or more aggressive, sometimes to the degree where it is classified as a different cancer. Even if two tumors originate from the same cell type in the same organ, their mutation profile will be different and thus in the end every tumor is a unique individual. 

Despite all this complexity, treatments in oncology have traditionally been much less complicated. “Pancreatic cancer” is treated with drugs X, Y and Z without regard for the individual characteristics of the tumor, and the same is true for most cancer types. Perhaps the most glaring example is sarcomas, which lumps more than 50 different tumor types together, but there are only a couple of widely used therapeutic regimens. In the past two decades treatment paradigms have changed somewhat for certain tumors such as lung, breast and colon cancer, and melanoma, where molecular subtypes are treated differently, increasing complexity in treatment choices. 

Immunotherapy has recently made a breakthrough into treatment of many types of cancers, including melanoma, lung, kidney, head and neck, urinary tract cancer, lymphoma and others. Amazingly, what has emerged is that from the point of view of immunotherapy, there seem to be only two types of tumors: Hot and Cold. 

The former type are characterized by the presence of tumor infiltrating lymphocytes (T-cells, a type of white blood cell), which are capable of recognizing aberrant proteins in or on cancer cells. Typically the easiest types of proteins to recognize are neoantigens (antigen = immunological target), which means proteins not normally found in the body. Certain types of mutation such as frameshift, point mutations, in-frame deletions and gene fusions can result in neoantigens. Neoantigens are more immunogenic (=able to cause an immune response) than overexpression or misplaced expression of normal antigens. Logically, the more mutations in the tumor, the more neoantigens, resulting in higher likelihood of T-cells detecting the tumor.

In theory, tumor-recognizing T-cells would be expected to kill the cells they detect. This probably happens all the time in our bodies, and we never knew that we had cancer. However, eventually some tumors are able to escape detection by the immune system, in a three-step process known as the three E’s of immunoevasion (Elimination, Equilibrium, Escape). Every tumor that is diagnosed has been able to escape killing by T-cells. One key mechanism is development of immunosuppression, meaning mechanisms that counteract detection and killing by immunological cells. These immunosuppressed tumors often feature expression of a molecule called PD-L1. For further reading on this please see my book referenced below.

In contrast to Hot tumors, Cold tumors don’t have a lot of mutations, often lack neoantigens and feature low or no T-cells inside the tumors. Since there is little cellular immunity against the tumor, there is less need for immunosuppression and therefore PD-L1 expression is typically low. One variant of a cold tumor is an “immune excluded” tumor where there might be mutations but because of certain biological reasons the T-cells are unable to penetrate the tumor. 

Fitting well with classification of tumors into two categories, Hot and Cold, there are two main types of immunotherapy treatment: 1) immune response inducing and 2) anti-immunosuppressive therapies.

Examples of the former category include cancer vaccines, T-cell therapies such as TIL, TCR and CART therapies, and oncolytic viruses, also known as oncolytic immunotherapy. Of these approaches, there is one CART approved for leukemia (tisagenlecleucel or Kymriah) and one oncolytic virus (talimogene laherparepvec or T-Vec or Imlygic) approved for treatment of melanoma. 

It seems likely many more drugs in these categories will be approved in the next decade. It has not been studied much but it could be that oncolytic viruses work best in Cold tumors, as proposed by Taipale and colleagues in 2016. Viruses such as adenovirus are able to destroy cancer cells in a manner which irritates the immune system, resulting in a T-cell dominated anti-tumor immune response, which can achieve prominent therapeutic effects if there was little or no immunosuppression present. 

A clearer breakthrough has already been seen in the latter category. The immunotherapies most widely used currently (eg nivolumab, pembrolizumab, atezolizumab, avelumab) block interaction between PD-L1 and its receptor PD-1. These “checkpoint inhibiting” drugs only work in Hot tumors characterized by neoantigens, T-cells and PD-L1 expression. They cannot generate new immunity and thus if T-cells were not present the therapy will probably not work. 

Oncologists love to mix and match ingredients to make their witches’ cocktails. Thus it comes as no surprise that oncolytic viruses have already been combined with checkpoint inhibitors, and trials were started even before the difference between Hot and Cold tumors was understood. These trials are still in their early phases or in planning but the initial data emerging is awesome. Ribas and collagues reported that the majority of patients responded emphatically without severe side effects, and one third had a complete response.

Although the combination of oncolytic virus with checkpoint inhibition is very well tolerated, it might represent overtreatment for some patients. It might be better to study the immunological status of tumors and treat Hot tumors with checkpoint inhibitors or their combinations, while Cold tumors could be treated with oncolytic viruses. Impressively, tests allowing distinguishing between Hot and Cold tumors were  rapidly incorporated into commercially available drug sensitivity kits such as OncoSTRAT&GO and Caris Molecular Intelligence. Thus, aficionados can already offer this testing to their patients.

Nevertheless, since generation of an immune response in the body always results in an immunosuppressive counter-response (this is how the body protects itself against auto-immunity), oncolytic viruses might benefit from an anti-immunosuppressive “companion treatment”. This would prevent dampening and attenuation of the anti-tumor response. 

Tumors have tremendous capacity for developing resistance, for example through a target-negative clone. Thus, there might be fewer relapses following checkpoint inhibition if it would be combined with a therapy such as an oncolytic virus that can increase the number and broaden the repertoire of tumor detecting T-cells. The beauty of the oncolytic approach is that it is dynamic and continuous – whichever epitopes are present in the tumor will be presented to the immune system. 

It is not trivial at all how these drugs are sequenced and dosed. Also, there are at least a dozen different types of oncolytic viruses but they are not likely to be equally effective in generating a T-cell dominated anti-tumor immune response. Likewise, there are dozens of potentially druggable immune checkpoints.
 
In summary, underlying incredible complexity between tumors, in the context of immunotherapy all tumors seems to fall into one of two classes: Hot or Cold. With regard to available immunotherapies, oncolytic viruses appear to work in Cold tumors while checkpoint inhibitors work in Hot tumors. The combination of these approaches is appealing and could become commonly used in the next decade. 

References

Hemminki A. Crossing the Valley of Death with Advanced Therapy. Published by Nomerta, Turku, Finland, 2015. Available at http://www.nomerta.net and several e-book stores globally

Ribas A, Dummer R, Puzanov I, VanderWalde A, Andtbacka RHI, Michielin O, Olszanski AJ, Malvehy J, Cebon J, Fernandez E, Kirkwood JM, Gajewski TF, Chen L, Gorski KS, Anderson AA, Diede SJ, Lassman ME, Gansert J, Hodi FS, Long GV. Oncolytic Virotherapy Promotes Intratumoral T Cell Infiltration and Improves Anti-PD-1 Immunotherapy. Cell. 2017 Sep 7;170(6):1109-1119.e10. doi: 10.1016/j.cell.2017.08.027.

Taipale K, Liikanen I, Koski A, Heiskanen R, Kanerva A, Hemminki O, Oksanen M, Grönberg-Vähä-Koskela S, Hemminki K, Joensuu T, Hemminki A. Predictive and Prognostic Clinical Variables in Cancer Patients Treated With Adenoviral Oncolytic Immunotherapy. Mol Ther. 2016 Aug;24(7):1323-32

25 comments:

  1. I am here to say thanks you to Dr Lucky my wife was
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    ReplyDelete
    Replies
    1. WHAT A GREAT MIRACLE THAT I HAVE EVER SEE IN MY LIFE. My names are Clara David I’m a citizen of USA, My younger sister was sicking of breast cancer and her name is Sandra David I and my family have taking her to all kind of hospital in USA still yet no good result. I decided to go to the internet and search for cancer cure so that was how I find a lady called peter Lizzy she was testifies to the world about the goodness of a herbal man who has the roots and herbs to cure all kind of disease and the herbal man email was there. So I decided to contact the herbal man @herbalist_sakura for my younger sister help to cure her breast cancer. I contacted him and told him my problem he told me that I should not worry that my sister cancer will be cure, he told me that there is a medicine that he is going to give me that I will cook it and give it to my sister to drink for one week, so I ask how can I receive the cure that I am in USA, he told me That I will pay for the delivery service. The courier service can transport it to me so he told me the amount I will pay, so my dad paid for the delivery fee. two days later I receive the cure from the courier service so I used it as the herbal man instructed me to, before the week complete my sister cancer was healed and it was like a dream to me not knowing that it was physical I and my family were very happy about the miracle of Doctor so my dad wanted to pay him 5 million us dollars the herbal man did not accept the offer from my dad, but I don't know why he didn't accept the offer, he only say that I should tell the world about him and his miracle he perform so am now here to tell the world about him if you or your relative is having any kind of disease that you can't get from the hospital please contact dr.sakuraspellalter@gmail.com or whats app him +2348110114739  you can follow him up on Instagram @herbalist_sakura for the cure, he will help you out with the problem. And if you need more information about the doctor you can mail me davidclara223@gmail.com 

      Delete
    2. I have been following this website for more than 2 years now, admin kindly post and share this to give other brain tumor patients hope that they can get a cure. Three years ago I was diagnosed with GBM after a CAT scan. I went through neurosurgery, radiation, and 14 months of chemo treatments but the symptoms all
      remained and even doubled, the constant thundering headache, seizures was twice than it was before, i could no longer think straight and i had constant mood swing and trouble speaking i was almost feeling at the gate of hell because these symptoms were unbearable. I am retired but very active spending my time to make the
      world a better place. BRAIN TUMOR mainly affects your brain and thus reduces your immunity thereby causing depression. The cure for BRAIN TUMOR is possible in the initial stages with natural herbal remedies. contact Doctor Emmanuel for your cure through his WHATS-APP NUMBER +2348140033827, or email, traditionalherbalhealingcentre@gmail.com for urgent delivery of your herbal cure asap. 

      Delete
    3. I am writing this comment with tears of joy a months ago i found out i was diagnosed with Herpes. I was heart broken, However that same month i was recommended to a Dr. who helped me to cured the virus with natural herbal treatment now i fully believed on natural treatment iam so happy thanks to Dr. ehiaguna. contact information: drehiaguna@gmail.com or massage him on WhatsApp +2348073908953 and and He also have herbs medicine to cured the following diseases; eczema,urethra wart,chronic problems.Herpes, Cancer, Als,Hepatitis, Diabetes, HPV,Infections,ulcer  ETC

      Delete
    4. I Never believed i was ever going to be HSV FREE again, DR.Ehiaguna has given me reasons to be happy, i was HSV positive for 2 years and all the means and medicine i tried for treatment was not helpful to me, but when i came on the Internet i saw great testimony about DR.Ehiaguna on how he was able to cure someone from HSV 2, this person said great things about this man, and advice we contact him for any Disease problem that DR.Ehiaguna can be of help, well i decided to give him a try, he requested for my information which i sent to him, and he told me he was going to prepare for me a healing portion, which he wanted me to take for days, and after which i should go back to the hospital for check up, well after taking all the treatment sent to me by DR.Ehiahuna , i went back to the Hospital for check up, and now i have been confirmed HSV NEGATIVE, friends you can reach DR.Ehiaguna on any treatment of any Disease cos i saw many testimony of different disease like, HEPATITIS,HIV AIDS,EPILEPSY, CANCER,CFS he is the one only one i can show you all up to, reach him on drehiaguna@gmail.com or whatsApp him now +2348073908953. quick contact him for help and you can just quickly drop your number on your first mail as i did for easily conversation

      Delete
    5. I'm 28 years old female I tested genital herpes (HSV1-2) positive in 2002. I was having bad outbreaks. EXTREMELY PAINFUL. I have try different kinds of drugs and treatment by the medical doctors all to know was avail. Six months ago I was desperately online searching for a helpful remedies for genital herpes (HSV1-2) cure, which i come across some helpful remedies on how Dr ehiaguna have help so many people in curing genital herpes (HSV1-2) with the help of herbal treatment because I too believe there is someone somewhere in the world who can cure herpes completely. As of the past 2 months, however, I've been following his herpes protocol Via drehiaguna@gmail.com and it stopped all outbreaks completely! To my greatest surprise I was cured completely by following the protocol of his herbal medicine . Don't be discouraged by the medical doctors. There is a cure for HSV with the help of herbs and roots kindly contact him for more information Via drehiaguna@gmail.com or Whatsapp him on +2348073908953 you can also visit his website https://effectiveherbalcurehome.blogspot.com/ He is capable of curing HIV/AIDS, HERPES, HPV, HSV1&2, CANCER of all kinds, DIABETES and so many other infections.

      Delete
  2. Beaver says I also have such interest, you can read my profile here: Tumors

    ReplyDelete
  3. If you have Herpes in your whole body such as fever blisters, hsv, or roofing shingles you know what it is like to stay with the pain and discomfort that herpes delivers. I don't need to tell you how awesome it would be to find something that works so well that you no longer need to fear about stress or outbreak,Dr Itua herbal medicine cure my herpes in two weeks of taking it.is genuine and natural herbal medicine it has no side effect, The reason I'm writing this is that I promised Dr Itua I will share his herbal work to the world to see Herpes is no more a big deal.also Dr Itua can as well cure the following diseases...HIV,Hsv 1/2,Hepatitis B,Breast Cancer, Cervical Cancer,Leukuemia Cancer,Lung Cancer,Brain CANCER,Blood Cancer,Prostate Cancer,Diabetes, Men/Woman Infertility, Scoliosis,Fibromyalgia,Fluoroquinolone ToxicitySyndrome Fibrodysplasia Ossificans Progressiva.Fatal Familial Insomnia Facator V Leiden Mutation ,   Lottery Spell,Copd, Shingles,Fibroid, Fibromyalgia, Liver/Kidney Inflamotry, Epilepsy,Hpv,Weak Erection,Wart Remover,Cold Sore,  Coeliac disease,Creutzfeldt–Jakob disease,Cerebral Amyloid Angiopathy, Glaucoma.Lupus, Lymne Disease,, Cataracts,Macular degeneration,Cardiovascular disease,Lung disease.Enlarged prostate,Osteoporosis.Alzheimer's disease,Dementia.Ataxia,Arthritis,Amyotrophic Lateral Sclerosis,Alzheimer's disease,Adrenocortical carcinoma.Asthma,Allergic   Asthma. Here His Contact...drituaherbalcenter@gmail.com/ . Whatsapp Phone.+2348149277976. I paid for his herbal medicine and sent it to me through Courier Service which I pick it urgently and used.  

    ReplyDelete
  4. AFRICAN TRADITIONAL METHODS OF CURING HERPES THAT IS GOING VIRAL!
    Most traditional methods of roots and herbs today have been scientifically proven to cure almost all drugs resistant diseases without after effect.
    It worked for me years ago when I was depressed with herpes. After trying numerous other methods, It was actually an old Ibo lady who brought to my notice the healing effect of natural medicines. She too was permanently cured from HERPES long time ago through Dr Utu @ "drutuherbalcure@gmail.com" who among few, specialises in African roots and herbs for medicinal cure. Apparently roots and herbs have well been known as effective key treatment for herpes. She introduced me to Dr Utu who till date remain my savior, and he truly cleared my doubt. After taking his medication on the fourth week, I contacted him again who asked me to go for test and I was negative. From then till now I do my normal business no outbreak. I may not be a herbal fan but it definitely worked for me!

    ReplyDelete
  5. I am here to give my testimony about Dr Ebhota who helped me.. i want to inform the public how i was cured from (HERPES SIMPLEX VIRUS) by salami, i visited different hospital but they gave me list of drugs like Famvir, Zovirax, and Valtrex which is very expensive to treat the symptoms and never cured me. I was browsing through the Internet searching for remedy on HERPES and i saw comment of people talking about how Dr Ehbota cured them. when i contacted him he gave me hope and send a Herbal medicine to me that i took for just 2 weeks and it seriously worked for me, my HERPES result came out negative. I am so happy as i am sharing this testimony. My advice to you all who thinks that there is no cure for herpes that is Not true just contact him and get cure from Dr Ebhota healing herbal cure of all kinds of sickness you may have like
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    HERPES. he also cure my friend from cervical cancer Email: drebhotasoultion@gmail.com or whatsapp him on +2348089535482

    ReplyDelete
  6. I'M Kelly FROM KENTUCKY.
    I wanna thank God for Using Dr. Odey Abang to restore my son's Happiness. He came from school crying that he was diagnosed of Herpes and his teacher and the Physician Therapist told him he could not get a cure rather living on drugs, he never talk to us about it anymore not knowing he plans committing suicide . I had to monitor him and explain to him that he should manage the prescribes ACYCLOVIR, , FAMCICLOVIR and the VALACYCLOVIR.
    4 months later, he told me about an Herbalist who he heard curing people from online and he sents through the DHL service. Not quite long,he brought his phone, had to speak with the Herbalist and explain how my son had really felt and desperate in need of the cures, he assured me with no site effects after taking the medicine and promise to do as he said, 5 days later, t medicine arrived, applied as instructed and within two weeks to finish,I had my son told me he was wondering why all this while,they have not approved the cures of which doctor ODEY told him he Cures.
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    If you're in trouble of health
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    Kindly contact him for more information on health and Safety solutions @
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    ReplyDelete
  7. WHAT A GREAT MIRACLE THAT I HAVE EVER SEE IN MY LIFE. My names are Clara David I’m a citizen of USA, My younger sister was sicking of
    breast cancer and her name is Sandra David I and my family have taking her
    to all kind of hospital in USA still yet no good result. I decided to go to
    the internet and search for cancer cure so that was how I find a lady
    called peter Lizzy she was testifies to the world about the goodness of a
    herbal man who has the roots and herbs to cure all kind of disease and the
    herbal man email was there. So I decided to contact the herbal man @herbalist_sakura for my younger sister help to cure her breast cancer. I contacted him and told him
    my problem he told me that I should not worry that my sister cancer will be
    cure, he told me that there is a medicine that he is going to give me that
    I will cook it and give it to my sister to drink for one week, so I ask how
    can I receive the cure that I am in USA, he told me
    That I will pay for the delivery service. The courier service can
    transport it to me so he told me the amount I will pay, so my dad paid for
    the delivery fee. two days later I receive the cure from the courier
    service so I used it as the herbal man instructed me to, before the week
    complete my sister cancer was healed and it was like a dream to me not
    knowing that it was physical I and my family were very happy about the
    miracle of Doctor so my dad wanted to pay him 5 million us dollars the
    herbal man did not accept the offer from my dad, but I don't know why he
    didn't accept the offer, he only say that I should tell the world about him
    and his miracle he perform so am now here to tell the world about him if
    you or your relative is having any kind of disease that you can't get from
    the hospital please contact dr.sakuraspellalter@gmail.com or whats app him
    +2348110114739  you can follow him up on Instagram @herbalist_sakura for the cure, he will help you out with the
    problem. And if you need more information about the doctor you can mail me
    davidclara223@gmail.com 

    ReplyDelete
  8. TESTIMONY ON HOW I CURED MY CANCER! . All thanks too @dr_adazal6Hey! I can,t believe this. A great testimony that i must share to all cancer patient in the world i never believed that their could be any complete cure for lung cancer or any cancer,i saw people testimony on blog sites of how @dr_adazal6  Simpson cannabis oil brought them back to life again. i had to try it too and you can’t believe that in just few weeks i started using it all my pains stop gradually and i had to leave without the drugs the doctor gave to me. Right now i can tell you that for months now i have not had any pain, and i have just went for text last week and the doctor confirmed that there is no trace of any cancer system. Glory be to God for leading me to this genuine Man Dr adazal Simpson. I am so happy as i am sharing this testimony. My advice to you all who thinks that their is no cure for cancer that is Not true, just contact him and get cannabis oil from dr.adazal  Simpson to cure your cancer and you will be free and free for ever, Try it and you will not regret it because it truly works. One thing i have come to realize is that you never know how true it is until you try. There is no harm in trying. Remember, delay in treatment leads to death. Here is his com Contact him and be free from cancer! I wish you a quick recovery WhatsApp number+. +2348073688335  or email via dr.adazalherbalcure@gmail.com

    ReplyDelete
  9. FINALLY FREE FROM HERPES VIRUSI thought my life had nothing to offer anymore because lifebecame meaningless to me because I had Herpes virus, thesymptoms became very severe and bold and made my familyrun from and abandoned me so they won't get infected. I gaveup everything, my hope, dreams,vision and job because thedoctor told me there's no cure. I consumed so many drugs butthey never cured me but hid the symptoms inside me makingit worse. I was doing some research online someday when Icame across testimonies of some people of how DR Ebhotacured them from Herpes, I never believed at first and thoughtit was a joke but later decided to contact him on the detailsprovided and when I messaged him we talked and he sent mehis herbal medicine and told me to go for a test after twoweeks. Within 7 days of medication the symptomsdisappeared and when I went for a test Lo and behold I wasNEGATIVE by the Doctor Who tested me earlier. Thank you DREbhota because I forever owe you my life and I'll keep ontelling the world about you. If you are going through samesituation worry no more and contact DR Ebhota viadrebhotasolution@gmail. com or WhatsApp him via +2348089535482.he also special on cureing 1. HIV/AIDS2. HERPES 3. CANCER 4.ALS 5. HEPATITIS B 6.DIABETES 7. HUMAN PAPILOMA VIRUS DISEASE(HPV)8. ALZHEIMER 9. LUPUS (Lupus Vulgaris or LupusErythematosus

    ReplyDelete
  10. I have been following this website for more than 2 years now, admin kindly post and share this to give other brain tumor patients hope that they can get a cure. Three years ago I was diagnosed with GBM after a CAT scan. I went through neurosurgery, radiation, and 14 months of chemo treatments but the symptoms all
    remained and even doubled, the constant thundering headache, seizures was twice than it was before, i could no longer think straight and i had constant mood swing and trouble speaking i was almost feeling at the gate of hell because these symptoms were unbearable. I am retired but very active spending my time to make the
    world a better place. BRAIN TUMOR mainly affects your brain and thus reduces your immunity thereby causing depression. The cure for BRAIN TUMOR is possible in the initial stages with natural herbal remedies. contact Doctor Emmanuel for your cure through his WHATS-APP NUMBER +2348140033827, or email, traditionalherbalhealingcentre@gmail.com for urgent delivery of your herbal cure asap. 

    ReplyDelete
  11. FINALLY FREE FROM CANCER DISEASE.
    what a miracle i never believe there is cure because my doctor tested me cancer positive and she told me there is no cure, i’m very happy today that i’m having a free life without this CANCER diseases, i can remember some months ago when i was crying all through the night and day that i can’t get cured from this CANCER, i found this herbal man called Dr adazal on internet when i was doing research on cure for shingle i contacted him to found out if i can get help from this cancer diseases, i was so surprise when he told me that he have the herbs cure to it and he sent me the herbal in less down 5 days i was so happy when i get someone giving me hope that he can cured me i took the herbal for just 2 weeks, when i went for test after taking the herbal i found out that i am cured i was so happy and surprise, i want to use this opportunity to inform you that there is cured to cancer diseases you can also contact him for his help as soon as possible so that you can get rid of this cancer once and for all you can reach him through this email: dr,adazalherblacure@gmail.com or whatsApp him on +2348073688335 You can also contact him on any disease and virus in this he all have the herbal cure to it.
    1 HIV/AIDS
    2 HERPES
    3 CANCER
    4 ALS
    5 HEPATITIS
    6 DIABETES
    7 LOVE SPELL
    8 INFECTIONS
    9 HIGN BLOOD PRESSURE,.....
    THANKS TO DR adazal FOE THE GOOD WORK IN LIFE YOU ARE TRULY A BLESS.  you can visti his fb page https://www.facebook.com/Dradazalherbalcure-113851246922332/  And Adazal   Website  https://dr-adazal-herbal-cure.jimdosite.com/

    ReplyDelete
  12. I am writing this comment with tears of joy a months ago i found out i was diagnosed with Herpes. I was heart broken, However that same month i was recommended to a Dr. who helped me to cured the virus with natural herbal treatment now i fully believed on natural treatment iam so happy thanks to Dr. ehiaguna. contact information: drehiaguna@gmail.com or massage him on WhatsApp +2348073908953 and and He also have herbs medicine to cured the following diseases; eczema,urethra wart,chronic problems.Herpes, Cancer, Als,Hepatitis, Diabetes, HPV,Infections,ulcer  ETC

    ReplyDelete
  13. I Never believed i was ever going to be HSV FREE again, DR.Ehiaguna has given me reasons to be happy, i was HSV positive for 2 years and all the means and medicine i tried for treatment was not helpful to me, but when i came on the Internet i saw great testimony about DR.Ehiaguna on how he was able to cure someone from HSV 2, this person said great things about this man, and advice we contact him for any Disease problem that DR.Ehiaguna can be of help, well i decided to give him a try, he requested for my information which i sent to him, and he told me he was going to prepare for me a healing portion, which he wanted me to take for days, and after which i should go back to the hospital for check up, well after taking all the treatment sent to me by DR.Ehiahuna , i went back to the Hospital for check up, and now i have been confirmed HSV NEGATIVE, friends you can reach DR.Ehiaguna on any treatment of any Disease cos i saw many testimony of different disease like, HEPATITIS,HIV AIDS,EPILEPSY, CANCER,CFS he is the one only one i can show you all up to, reach him on drehiaguna@gmail.com or whatsApp him now +2348073908953. quick contact him for help and you can just quickly drop your number on your first mail as i did for easily conversation

    ReplyDelete
  14. HERPES is a serious and recurrence disease which can't be cure through drugs or injections by an American doctors but the best way to deal with Herpes is by taking natural herbs medicine for it, I have red about DR JAMES the great herbalist doctor who cured me from herpes with his powerful herbal medicine. I contacted him to know how he can help me and he told me never to worry that he will help me with the natural herbs!After 2 days of contacting him, he told me that the cure has been ready and he sent it to me via UPS SPEED POST and it got to me after 3 days i used the medicine as he instructed me (MORNING and EVENING) and i was cured!it's really like a dream but I am so happy! for the people suffering from herpes virus and any kind of diseases such as Alzheimer’s disease,Bechet’s disease,Crohn’s disease,Parkinson's disease,Schizophrenia,Lung Cancer,Breast Cancer,Colo-Rectal Cancer,Blood Cancer,Prostate Cancer,siva.Fatal Familial Insomnia Factor V Leiden Mutation ,Epilepsy Dupuytren's disease,Desmoplastic small-round-cell tumor Diabetes ,Coeliac disease,Creutzfeldt–Jakob disease,Cerebral Amyloid Angiopathy, Ataxia,Arthritis,Amyotrophic Lateral Sclerosis,Fibromyalgia,Fluoroquinolone Toxicity
    Syndrome Fibrodysplasia Ossificans ProgresS sclerosis,Seizures,Alzheimer's disease,Adrenocortical carcinoma.Asthma,Allergic diseases.Hiv_ Aids,Herpe ,Copd,Glaucoma., Cataracts,Macular degeneration,Cardiovascular disease,Lung disease.Enlarged prostate,Osteoporosis.Alzheimer's disease,
    Dementia.Lupus.
    ,Cushing’s disease,Heart failure,Multiple Sclerosis,Hypertension,Colo_Rectal Cancer,Lyme Disease,Blood Cancer,Brain Cancer,Breast Cancer,Lung Cancer,Kidney Cancer, HIV, Herpes,Hepatitis B, Liver Inflammatory,Diabetes,Fibroid,
    should contact him for his herbal medicine because i am a living testimony and i was cured of herpes and his medicine is legit. I sent him what he requested and he sent me his medicine which I took for 2 good weeks and today I am out here with a negative result. When I went for the test I was so happy after taking his herbal medication I paid homage to his country to celebrate with him on his African festival which he told me it usually happens every year. you can reach him through VIA E-mail drjamesherbalmix@gmail.com or whatsapp number:+2348152855846

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  15. I'm 28 years old female I tested genital herpes (HSV1-2) positive in 2002. I was having bad outbreaks. EXTREMELY PAINFUL. I have try different kinds of drugs and treatment by the medical doctors all to know was avail. Six months ago I was desperately online searching for a helpful remedies for genital herpes (HSV1-2) cure, which i come across some helpful remedies on how Dr ehiaguna have help so many people in curing genital herpes (HSV1-2) with the help of herbal treatment because I too believe there is someone somewhere in the world who can cure herpes completely. As of the past 2 months, however, I've been following his herpes protocol Via drehiaguna@gmail.com and it stopped all outbreaks completely! To my greatest surprise I was cured completely by following the protocol of his herbal medicine . Don't be discouraged by the medical doctors. There is a cure for HSV with the help of herbs and roots kindly contact him for more information Via drehiaguna@gmail.com or Whatsapp him on +2348073908953 you can also visit his website https://effectiveherbalcurehome.blogspot.com/ He is capable of curing HIV/AIDS, HERPES, HPV, HSV1&2, CANCER of all kinds, DIABETES and so many other infections.

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  16. I want to write a little testimony about the good work of doctor Ebhota who cured me from Hsv 1 and 2 for just 2 week with his herbal medicine, I never believe I can be normal again and have a good life like others I always regretted the day I got diagnose with the virus, I was lost of hope when my doctor told me there is no cure for it but I keep thinking and thinking about my future, if I can have kids of my own well I am so grateful for my helper who get me cured with his herbal medicine, I go online in search of anything that can help me because I can’t deal with it forever so I found this Dr Ebhota email on a blog of someone who was cured by him I quickly contact him for help and explain all my pain to him, he told me not to worry about it there is cure for real, I never believe until he send me the herbal medicine when I order for it and I have it within 4 days that is how I took the medicine for 2 week and the following week I go for test just to confirm I was 100% cured from this sickness what a miracle in my life I am so happy right now, you can also get in contact with him if you have such sickness through drebhotasolution@gmail.com and also WhatsApp him +2348089535482.../https://drebhotasolution.wixsite.com/drebhotaherbalhome he can also help with this following sickness DIABETES CURE/EPILESY/HPV/CURE/LUPUS/
    HEPATITIS56

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  17. Hey plz share this I am here to testify how a herbal helped me out with herbs and roots which he prepared for me in use of curing Herpes.natural remedy work perfectly I takes the product which he prepared for me for some few days before I am to know I was totally cured out of it. Please you need to reach him in any similar illness, his product is helpful and it heals perfectly...his info drdestinyspellhome@gmail.com his calling WhatSapp number +2348105074556 Communication with facebook page: https://web.facebook.com/Doctor-Destiny-106008014979860

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  18. I'm so excited to share my testimonies about the Good Work of Dr Destiny who use his natural herbs to cure my Hepatitis B disease I suffered from 3years, but now I am a happy woman and i am free from this disease that has been problem to my living, after using Dr Destiny herbal medicine within 2week i was diagnose negative, I will recommend Dr Destiny to everyone reading this article because this herbal The healer is capable of healing anything below.

    1. Diabetes
    2. HERPES 1/2
    3. CANCER
    4. HIV
    5. HPV
    6. Fibroid
    7. Fibromyalgia

    Email Dr Destinny at: drdestinyspellhome@gmail.com add Dr Destiny on
    whatsApp: +2348105074556 Communication with facebook page: https://web.facebook.com/Doctor-Destiny-106008014979860

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  19. Hello, everyone! I'm here to explore blogs and forums about the wonderful and most safe cure for (Herpes Virus). I was positive about the deadly virus called herpes and I lost hope because I was outcast and rejected even by my closest friends. I searched on-line to know an enquirer cure for Herpes and I read someone's testimony on how he was cured from Herpes so I decided to contact the same herbalist because I know that nature has the power to heal everything. I contacted him to know how he can help me and he told me never to worry that he will heal me with the natural herbs from God! After 2 days of contacting him, he told me that the cure has been ready and he sent it to me via DHL and it got to me after 3 days! I used the med as he instructed (MORNING and EVENING) and i was cured! it's really like a dream but I am so happy! That's the reason I decided to also add more comments on Him so that more can be saved just like me! and you can get in touch with him via email chiefdrlucky@gmail.com or WhatsApp  +2348132777335 Kindly visit website https://chiefdrluckyherbaltherapy.wordpress.com/

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  20. I got Diagnosed with Herpes, I have be dealing with Herpes for the past 4 years. On till I got review online about natural cure people testifies how DR. Ehimare cure them with his herbal treatment. And I order the treatment, after taking it for 21 days I totally got cured with DR. Ehimare treatment. I'm recommending you diagnosis with herpes should get this treatment and be cured of it you can contact his email address via; drehimare3@gmail. com or you can also call or whatsapp +1 (267) 691-1087Dr. Ehimare also cure the following virus and many more... 1} Cancer 2} Diabetes 3} Hepatitis 4} fibroid 5} herpes 6} Lupus  

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